Ascorbic Acid as an Inhibitor for SARS-CoV-2 Virus Reproduction: A Theoretical Approach
نویسندگان
چکیده
In the present study, ascorbic acid’s or Vitamin C’s influence (VC) in inhibition of SARS-CoV-2 virus reproduction was investigated. Gaussian 09 with a basis set 6-311G (d, p), MGL tools, DSV, and LigPlus software were used. According to Total Electron Density (TED) Millikan charges, active sites for adsorption determined. Further, docking study had clearly revealed role VC accordance binding energy (Eb) ligand efficiency (LE). The vitamin’s interaction virus’s spikes may limit its replication provide immune system sufficient time recognize infection, which enhances possibility producing appropriate antibodies.
منابع مشابه
Investigating the Mechanism of Action of SARS-CoV-2 Virus for Drug Designing: A Review
Coronavirus Disease 2019 (COVID-19) is a viral pneumonia emerged in December 2019 in Wuhan, China. Its cause is a new virus from the coronavirus family scientifically named Coronavirus Acute Respiratory Syndrome 2 (SARS-CoV-2). In this review study, articles published in English until March 23, 2020 on new coronavirus infection were reviewed. These articles are obtained by searching in PubMed, ...
متن کاملSARS-COV-2 Virus; Immune Responses and The Immunopathogenesis
Abstract Background and Objectives Clinical features of SARS-COV-2 virus include fever, headache, cough, sore throat, and shortness of breath, and in severe forms it leads to disseminated intravascular coagulation, septic shock, and ultimately death. Excessive secretion of proinflammatory cytokines such as TNF-α, IL-6, and IL-1 leads to cytokine storms in this disease. The emergence of new va...
متن کاملEffects of SARS-CoV-2 Virus on Thyroid Function: A Narrative Review
SARS-CoV-2 is a type of coronavirus that causes COVID-19 disease. The virus can infect various organs by triggering hormones, regulatory and messenger molecules, and immune-inflammatory responses. Given the vital role of thyroid in metabolism, it is important to understand the potential effects of SARS-CoV-2 on the thyroid gland. In this article, reports and studies examining the effects of SAR...
متن کاملSerology Testing for SARS-CoV-2: Benefits and Challenges
As COVID-19 was declared as a pandemic by the World Health Organization (WHO) in March 2020, it is an emerging need to discuss different aspects of this pandemic. In any pandemic, valid and rapid laboratory diagnostic tests are critically important for early diagnosis, which will increase the rate of successful treatment and more importantly prevent the spread of the disease.
متن کاملSARS-CoV-2: A Review Of Present & Future Perspectives
As the dawn of this new decade has begun, we have faced our arch-nemesis right at the start in the form of Coronavirus also known as COVID-19. Since its origin from Wuhan, China, it has been declared a pandemic and has effected several countries worldwide. This review article summarizes all the research, techniques, strategies, and treatment methodologies that are taking place internationally i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of communicable diseases
سال: 2021
ISSN: ['0019-5138', '2581-351X']
DOI: https://doi.org/10.24321/0019.5138.202155